Pdf central giant cell granuloma of the jaw

Pdf central giant cell granuloma is an uncommon, benign, and proliferative lesion whose. Central giant cell granuloma cgcg is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. Interventions for central giant cell granuloma cgcg of the. Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. An aggressive central giant cell granuloma in a pediatric patient. Shows preop considerations, the operative removal, and properties of the giant cell granuloma. Uses microscopic slides and shows postops of 1,4,and 7 months. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible expansion of.

Central giant cell granuloma and fibrous dysplasia. We present a case of an aggressive central giant cell granuloma. Primary hyperparathyroidism presented as central giant cell. Central giant cell granuloma cgcg involving either jaw is not a common benign intraosseous lesion containing giant cells.

It is a localized osteolytic lesion with the varied biologic behavior of aggression which affects the jaw. Traditional treatment has been local curettage, although aggressive subtypes. The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of. Conventional management is surgical and consists of enucleation and curettage. Recurrent central giant cell granuloma in the mandible. As the distribution of immunostaining is identical to that observed in giant cell tumor of bone, our results support the possibility that central giant cell granuloma of the jaws and giant cell tumor of bone represent a similar disease process that clinically and histologically may have somewhat different features because of differences in the. The microscopic appearance of the central giant cell. Central giant cell granuloma cgcg is an infrequent benign intraosseous lesion that affects solely the jaw bones with unpredictable clinical expression. In 1953, jaffe described it as reparative granuloma of jaw bones. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs. A retrospective analysis of a 20year database was performed regarding both clinical and radiological features of 22 patients affected with cgcgs of the jaws. Whether cgcg is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains. Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones gargi s.

We present a case of an aggressive central giant cell granuloma cgcg in a six yearold female. Clinical and radiological features of central giant cell lesions of the jaw. I971 described the central giant cell granuloma as occurring between the ages of 10 and 25 years. Central giant cell granuloma of the jaws springerlink. Central giant cell granuloma of the jaw is considered a nonneoplastic lesion. It is described as a rare benign tumor of the jaws with an unknown cause accounting for up to 7% of jaw tumors, 2 and by far the most common of giant cell. It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell tumor of long bones.

Case report giant cell tumor of the maxilla in an 8 year old boy sabhlok s1, shaikh mi2. Idiopathic bilateral central giant cell granuloma of jaw. Central giant cell granuloma cgcg is an uncommon, benign, proliferative, and nonodontogenic lesion whose etiology is not defined. Radiologic features of central giant cell granuloma of the jaws. The etiology and clinical behaviour of giant cell lesions are still debatable. It is a localized osteolytic lesion with the varied biologic behavior of aggression which affects the jaw bones. Central giant cell granuloma cgcg of the jaws and giant cell tumor gct of bone share a number of similarities and dissimilarities in respect of their histopathological, cytometric and. Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. The common therapy is curettage or resection, which may be associated with.

Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Central giant cell granuloma cgcg as introduced for the first time by jaffe in 1953 is a reactive lesion to an intraosseous hemorrhage, which was clinically different from a true giant cell tumor of jaw with. An aggressive central giant cell granuloma treated successfully by. Giant cell granulomas gcgs of the jaws are lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Interventions for central giant cell granuloma of the jaws. An aggressive central giant cell granuloma in a pediatric. Cgcg was formerly regarded as a reparative process and was, accordingly, called central giant cell reparative granuloma. Central giant cell granuloma of the mandible youtube. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma.

For the previously reported cases in one female and three males, the. In this video, we are going to look at lesions of the jaw bones that have multinucleated giant cells microscopically. Genetic profiling of central giant cell granuloma of the. Central giant cell granuloma cgcg is defined by the world health organization as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multiple nucleated giant cells, and occasionally trabeculae of woven bone. Intralesional steroid treatment of central giant cell. Central giant cell granuloma was first described by jaffe in 1953.

It is an uncommon, benign and proliferative non neoplastic process. Central giant cell granuloma of the mandible american. But the term reparative is obsolete, as cgcg causes the destruction of involved bones. It ranges from slowgrowing, asymptomatic swelling to an aggressive. Initially they were thought to be related to teeth in some way, although they were not considered completely odontogenic in origin. Primary hyperparathyroidism presented as central giant. Central giant cell granuloma of the jaws and giant cell. Central giant cell granuloma of jaw with multiple, multifocal. Central giant cell granuloma, fibrous dysplasia introduction central giant cell granuloma and fibrous dysplasia are relatively uncommon lesions1. Central giant cell granuloma cgcg is a lesion that appears to be unique to the jaws, 1115 although the socalled giant cell reaction of the hands and feet shares many features. As the distribution of immunostaining is identical to that observed in giant cell tumor of bone, our results support the possibility that central giant cell granuloma of the jaws and giant cell tumor of bone.

Pdf giant cell lesion and central giant cell granuloma of. The true nature of this lesion is controversial and remains unknown. Central giant cell granuloma is considered widely to be nonneo. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. Casereport munzenmayer j1, tapia p 2, zeballos j, martinez a 3, compan a4, urra a 5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. Giant cell granuloma of the jaw is a benign lesion that may cause local destruction of bone and displacement of teeth. The clinical behavior of central giant cell granuloma cgcg of the jaws is variable and difficult to predict. The diagnosis and management of giant cell lesions of the jaws. Idiopathic bilateral central giant cell granuloma of jaw a. Central giant cell granuloma and fibrous dysplasia occurring. Central giantcell granuloma cgcg is a localised benign condition of the jaws.

The microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in hyperpituitarism. Bilateral central giant cell granuloma of the mandibular. To determine the demographic, clinical and radiographic features of the central giant cell granulomas cgcg of jaws. Incidence and diseasefree survival after surgical therapy of central giant cell granulomas of the jaw in the netherlands. Aggressive central giant cell granuloma of the mandible, a. Oral peripheral and central giant cell granulomas are lesions with littleknown etiology and pathogenesis. Apr 17, 2015 central giant cell granuloma was 1st described in jaws by jaffe 1953. It is a noncancerous condition that is usually painless, but irritation and open lesions in the mouth can lead. Central giantcell granuloma of the jaw a hormonal influence. Radiotherapy for recurrent central giant cell granuloma. Thought to represent a reparative response to intrabony haemorrhage and inflammation, cgcg was once regarded as a reactive lesion. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. Giant cell lesions of the jaw include cherubism, central giant cell granuloma cgcg peripheral giant cell granuloma pgcg aneurysmal bone cyst, traumatic bone cyst and jaw tumour of hyperparathyroidism.

Central giant cell granuloma cgcg is an uncommon, benign, and proliferative lesion of the jaw with an unknown etiology. The central giant cell granuloma cgcg was first described by jaffe in 1953 as a giant cell reparative granuloma of the jaw bones. The lesions occur more frequently in females than in males and are more often located in the mandible than in the maxilla. Treatment of central giant cell granuloma of the jaw with calcitonin. Fibrous dysplasia fd is a developmental tumor like condition that is characterized by. Cellular cannibalism in giant cells of central giant cell. Giant cell granuloma an overview sciencedirect topics.

The central giant cell granuloma cgcg is considered a benign, nonneoplastic lesion of bone found in a younger. Central giant cell granuloma of the maxilla bmj case reports. Thought to represent a reparative response to intrabony haemorrhage and. Central giant cell granuloma is a benign intraosseous lesion. Central giant cell granuloma was 1st described in jaws by jaffe 1953. Central giant cell granuloma involving mandible a report. Central giant cell granuloma cgcg of the jaw bones is a rare benign intraosseous lesions that is commonly seen as indolent lesions in the mandible anterior to the first molar. Uvadare digital academic repository central giant cell. Central giant cells granuloma, cherubismlike lesions, case series main text central giant cell granuloma cgcg is defined by the world health organization as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multiple nucleated giant cells, and occasionally. A central giant cell granuloma is a type of bone lesion that appears along the jaw. Histologically, both peripheral and central giant cell granuloma.

Central giant cell granuloma cgcg is a benign lesion of the jaws, facial bones and the skull of unknown etiology 8. Treatment of central giant cell granuloma of the jaw. Improvement of giant cell lesions of the jaw treated with. Central giant cell granuloma and fibrous dysplasia occurring in the same jaw is rarely reported in the literatures. Pdf central giant cell granuloma of mandible mohit.

Genetic profiling of central giant cell granuloma of the jaw. It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell. In addition, differentiating between aggressive and nonaggressive central giant cell granuloma. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. Occurrence of multiple giant cell lesions in the jaw. A 3yearold boy presented with a limp and 6 months later with painless growth of the jaw. Different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. Giant cell lesions of the bone comprise a group of jaw bone pathologies.

Central giant cell granulomas of the condyle are rare. The microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in for which of the following pathological conditions would a lower central incisor tooth. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. It is a benign lesion but sometimes an aggressive osteolytic proliferation consisting of fibrous tissue with osteoclastlike giant. The incidence in the general population is very low and patients are generally younger than 30 years. Central giant cell granuloma is considered widely to be nonneoplastic lesion. The etiology is unknown, but is thought to be a reactive process, possibly secondary to trauma or inflammation. Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Central giant cell granuloma cgcg or giant cell lesions are reported commonly in females and in first two decades of life. Central giant cell granuloma is an uncommon benign proliferative lesion occurring more commonly in the anterior mandible.

The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Also called giant cell reparative granuloma central if intraosseous. Case report giant cell tumor of the maxilla in an 8 year old boy.

Jaffe hl 1953 giantcell reparative granuloma, traumatic bone cyst and. The objective was to investigate the clinical and radiological characteristics of central giant cell granulomas cgcgs of the jaws. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing jaw lesions. Whitaker sb, waldron ca 1993 central giant cell lesions of the jaws. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made.

Central giant cell granuloma cgcg as introduced for the first time by jaffe in 1953 is a reactive lesion to an intraosseous hemorrhage, which was clinically different from a true giant cell tumor of jaw with diverse clinical behaviour pattern1. Tumorinduced rickets in a child with a central giant cell. Who categorize it as a bonerelated lesion, not a tumor, although its clinical behavior and. Case report giant cell tumor of the maxilla in an 8 year. Theselesionsconstituteabout7%ofall benign jaw tumours 3 and are divided into aggressive and. The aim of this study was to compare matrix metalloproteinases2 and osteopontin protein expression in the multinucleated giant cells and mononuclear cells of the peripheral and central giant cell granuloma lesions. It may become aggressive leading to expansion and perforation of the cortex. Giant cell lesion granuloma oral lesions jaws bone. The term central giant cell lesion has been proposed as a. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing of all benign jaw lesions. Sarode department of oral pathology and microbiology, dr d. Despite this, a recurrence rate of 1520% is often quoted, and in these cases treatment may need to be more aggressive and may need to consist of an en bloc resection. The neoplastic status of the central giant cell granuloma of the jaws remains an unsolved contro versy in anatomic pathology. Aggressive lesion can cause jaw to swell, and loosen teeth.

It is twice as common in females and is more likely to occur before age 30. Despite this, a recurrence rate of 1520% is often quoted, and in. Panders 1973 records an age range of between five and 65 years for central giant cell. Central giant cell granuloma cgcg of the jaws is a central osteolytic lesion characterized histologically by multinucleated giant cells in a background of ovoid to spindleshaped mesenchymal cells. Clinical data and followup information of 26 patients with cgcg were analyzed. Central giant cell granuloma cgcg is a localised benign condition of the jaws. The central giant cell granuloma cgcg is considered a benign, nonneoplastic lesion of bone found in a younger age group who are usually less than 30 years of age.

A case report in a child mk gupta, sg naidu, vj maheshwari. The central giant cell granuloma is an uncommon, benign and proliferative lesion whose etilogy is not well defined. We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma cgcg with high serum levels of fgf23, a hormone associated with decreased phosphate resorption. Central giant cell granuloma of the mandibular condyle. This observational study was conducted at outpatient department of oral and dental hospital, khyber college of dentistry peshawar and private clinics at peshawar, nowshera, mardan and kohat, from june 2006 to may 2018. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. This is a really good category of lesions to remember for the test. Panoramic dental xrays showed a 25mm 15mm radiolucent lesion in the right posterior mandible fig. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg.